Description

Boc-5-Chloro-L-Tryptophan is a protected derivative of the essential amino acid L-tryptophan, featuring a tert-butoxycarbonyl (Boc) protecting group on the amine and a chloro substituent on the indole ring. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, offering enhanced stability and controlled reactivity during solid-phase and solution-phase peptide synthesis. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including peptide-based drugs and bioactive probes.

Application

• Pharmaceutical Intermediates: Serves as a key chiral synthon in the research and development of peptide-based pharmaceuticals and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: A fundamental building block for the controlled incorporation of modified tryptophan residues into custom peptides using Boc-chemistry strategies.
• Biochemical Research: Used in the study of enzyme-substrate interactions, receptor binding, and the structure-activity relationships (SAR) of peptides.
• Proteomics & Labeling: Can be utilized for the synthesis of labeled peptides or as a precursor for fluorescent or affinity tags in proteomic studies.
• Agrochemical Research: Employed in the discovery and synthesis of novel peptide-inspired bioactive compounds for crop protection.

Basic Information

Product Name	Boc-5-Chloro-L-Tryptophan
CAS No.	114873-08-4
Molecular Formula	C₁₆H₁₉ClN₂O₄
Molecular Weight	338.79 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]-3-[5-chloro-1H-indol-3-yl]propanoic acid; N-(tert-Butoxycarbonyl)-5-chloro-L-tryptophan; Boc-5-Cl-L-Trp-OH; 5-Chloro-N-Boc-L-tryptophan; Boc-L-Trp(5-Cl)-OH; N-Boc-5-chlorotryptophan; tert-Butyl (S)-(1-(5-chloro-1H-indol-3-yl)-1-oxo-3-propan-2-yl) carbamate (related); 5-Chloro-1H-indole-3-propanoic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-, (αS)-
EINECS	Contact for details

Quality Control

Our Boc-5-Chloro-L-Tryptophan is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.