Description

Boc-L-2-Methylphe CAS NO 114873-05-1 is a protected amino acid derivative, specifically the tert-butoxycarbonyl (Boc) derivative of L-2-methylphenylalanine. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, offering enhanced stability and orthogonal protection strategies during solid-phase and solution-phase peptide synthesis. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, bioactive peptides, and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase peptide synthesis (SPPS) and solution-phase methods to incorporate the non-natural amino acid 2-methylphenylalanine into peptide sequences.
• Bioconjugation & Probe Development: Serves as a building block for creating labeled peptides, imaging probes, and bioconjugates for diagnostic and research applications.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to modulate the pharmacokinetic and pharmacodynamic properties of peptide leads.
• Biochemical Tool Development: Utilized in the synthesis of enzyme substrates, inhibitors, and other biochemical tools for proteomics and enzymology research.

Basic Information

Product Name	Boc-L-2-Methylphe CAS NO 114873-05-1
CAS No.	114873-05-1
Molecular Formula	C₁₅H₂₁NO₄
Molecular Weight	279.33 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]-3-(2-methylphenyl)propanoic acid; Boc-2-MePhe-OH; N-(tert-Butoxycarbonyl)-2-methyl-L-phenylalanine; N-Boc-2-methyl-L-phenylalanine; Boc-L-2-methylphenylalanine; tert-Butyl (2S)-2-amino-3-(2-methylphenyl)propanoate; (S)-2-((tert-Butoxycarbonyl)amino)-3-(o-tolyl)propanoic acid
EINECS	Contact for details

Quality Control

Our Boc-L-2-Methylphe is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.