Description

Boc-L-3-Fluorophenylalanine is a protected, non-natural amino acid derivative essential for advanced peptide synthesis and medicinal chemistry research. This high-purity building block enables the precise incorporation of a fluorinated aromatic side chain, a critical modification for studying structure-activity relationships and enhancing metabolic stability in drug candidates. It is primarily utilized by pharmaceutical R&D teams, CROs, and fine chemical manufacturers developing novel therapeutics, including peptide-based drugs and protease inhibitors.

Application

• Pharmaceutical Intermediate: A key building block in the solid-phase and solution-phase synthesis of novel peptide therapeutics and bioactive compounds.
• Protease Inhibitor Development: Used to create fluorinated peptide analogs for studying enzyme-substrate interactions and designing potent inhibitors.
• PET Tracer Precursor: Serves as a precursor in the synthesis of fluorine-18 labeled compounds for Positron Emission Tomography (PET) imaging agents.
• Medicinal Chemistry Research: Facilitates structure-activity relationship (SAR) studies by introducing a fluorine atom to modulate lipophilicity, bioavailability, and binding affinity.
• Bioconjugation & Labeling: Employed in the site-specific modification of peptides and proteins for diagnostic and therapeutic applications.
• Academic & Industrial R&D: A fundamental reagent in university and corporate laboratories focused on organic synthesis and chemical biology.

Basic Information

Product Name	Boc-L-3-Fluorophenylalanine
CAS No.	114873-01-7
Molecular Formula	C₁₄H₁₈FNO₄
Molecular Weight	283.30 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)amino)-3-(3-fluorophenyl)propanoic acid; N-(tert-Butoxycarbonyl)-3-fluoro-L-phenylalanine; Boc-3-F-Phe-OH; Boc-L-3-Fluoro-Phe; N-Boc-3-fluoro-L-phenylalanine; tert-Butyloxycarbonyl-3-fluoro-L-phenylalanine; Fmoc-L-3-Fluorophenylalanine (precursor related); BOC-PHE(3-F)-OH
EINECS	Contact for details

Quality Control

Our Boc-L-3-Fluorophenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive identification tests. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.