Description

4-(Trifluoromethyl)-D-Phenylalanine is a non-natural, fluorinated amino acid derivative of significant interest in advanced pharmaceutical and agrochemical research. Its core value lies in the unique properties imparted by the trifluoromethyl group, which can dramatically enhance metabolic stability, lipophilicity, and bioavailability in lead compounds. This high-purity chiral building block is essential for medicinal chemists and R&D professionals in the pharmaceutical, biotechnology, and agrochemical sectors seeking to develop novel therapeutics and active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of peptide-based drugs and protease inhibitors.
• Medicinal Chemistry Research: Used to incorporate fluorine into lead compounds to optimize ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) properties.
• Agrochemical Development: Serves as a building block for novel herbicides and pesticides with improved efficacy and environmental profile.
• Peptide Modification: Enables the creation of modified peptides with enhanced stability against enzymatic degradation.
• Bioconjugation & Probe Development: Useful for labeling and bioconjugation applications in biochemical research and diagnostic assays.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in stereoselective synthetic routes.

Basic Information

Product Name	4-(Trifluoromethyl)-D-Phenylalanine
CAS No.	114872-99-0
Molecular Formula	C₁₀H₁₀F₃NO₂
Molecular Weight	233.19 g/mol
Synonyms	(R)-2-Amino-3-[4-(trifluoromethyl)phenyl]propanoic acid; D-4-(Trifluoromethyl)phenylalanine; (R)-4-(Trifluoromethyl)phenylalanine; D-α-Amino-4-(trifluoromethyl)benzenepropanoic acid; 4-CF3-D-Phe; D-Phe(4-CF3)-OH; Fmoc-D-4-(trifluoromethyl)phenylalanine (precursor)
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)-D-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (D-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.