Description

Carvedilol B-D-Glucuronide is a major, pharmacologically relevant metabolite of the β-blocker carvedilol, formed via glucuronidation. This compound is crucial for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics (PK), and bioanalytical method validation. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in metabolite identification, ADME studies, and the production of reference standards.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantification and qualification of carvedilol metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Research: Essential for in vitro and in vivo studies to understand the metabolic pathways and clearance mechanisms of carvedilol.
• Bioanalytical Method Development: Used as a critical calibrant and quality control sample in HPLC-MS/MS and LC-MS assays for therapeutic drug monitoring and clinical studies.
• Metabolite Synthesis and Characterization: Acts as a starting material or intermediate for the synthesis of other labeled or derivative metabolites for advanced research.
• Regulatory Submissions: Supports investigative new drug (IND) and new drug application (NDA) filings by providing characterized metabolite data.

Basic Information

Product Name	Carvedilol B-D-Glucuronide
CAS No.	114869-83-9
Molecular Formula	C30H40N2O10
Molecular Weight	588.65 g/mol
Synonyms	Carvedilol Glucuronide; Carvedilol β-D-Glucuronide; 1-[9H-Carbazol-4-yloxy]-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol β-D-Glucopyranosiduronic Acid; (2S,3S,4S,5R,6S)-6-[4-({2-Hydroxy-3-[4-(9H-carbazol-9-yloxy)-3-hydroxyphenyl]propyl}[2-(2-methoxyphenoxy)ethyl]amino)butoxy]-3,4,5-trihydroxyoxane-2-carboxylic Acid; Carvedilol Metabolite M4; Carvedilol B-D-Gluc
EINECS	Contact for details

Quality Control

Our Carvedilol B-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.