Description

(2R,4R)-n-tert-Butoxycarbonyl-4-(Dicyclohexylphosphino)-2-[(Diphenylphosphino)Methyl]Pyrrolidine is a high-value, chiral phosphine ligand critical for asymmetric catalysis. Its primary value lies in enabling highly enantioselective transformations, which are essential for the efficient synthesis of single-enantiomer pharmaceuticals and fine chemicals. This compound is specifically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for pharmaceutical intermediate synthesis.
• Catalyst component for enantioselective C-C bond formation (e.g., cross-coupling, allylic alkylation).
• Key reagent in the development of stereoselective synthetic routes for active pharmaceutical ingredients (APIs).
• Use in academic and industrial research for exploring new catalytic methodologies.
• Potential application in the synthesis of specialty chemicals and flavors & fragrances requiring high optical purity.
• Catalyst for asymmetric isomerization and hydrofunctionalization reactions.

Basic Information

Product Name	(2R,4R)-n-tert-Butoxycarbonyl-4-(Dicyclohexylphosphino)-2-[(Diphenylphosphino)Methyl]Pyrrolidine
CAS No.	114751-47-2
Molecular Formula	C35H51NO2P2
Molecular Weight	579.73 g/mol
Synonyms	(2R,4R)-Boc-PHOX; (2R,4R)-tert-Butoxycarbonyl-4-(dicyclohexylphosphino)-2-[(diphenylphosphino)methyl]pyrrolidine; (R,R)-Boc-PHOX Ligand; (2R,4R)-Boc-Protected PHOX Ligand; (2R,4R)-N-Boc-4-(Dicyclohexylphosphino)-2-[(Diphenylphosphino)Methyl]Pyrrolidine; (2R,4R)-4-(Dicyclohexylphosphino)-2-[(diphenylphosphino)methyl]-1-(tert-butoxycarbonyl)pyrrolidine; (R,R)-t-Boc-PHOX; PHOX-Boc (R,R)-isomer
EINECS	Contact for details

Quality Control

Our (2R,4R)-Boc-PHOX ligand is manufactured under strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, critical for reproducible catalytic performance. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity, chemical purity, and identity confirmation. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. This compound is easily oxidized and moisture-sensitive; prolonged exposure to air or ambient conditions should be avoided. The storage area should be cool, dry, and well-ventilated.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.