Description

D-Proline, 3-Hydroxy-5-Methyl-, (3R,5R)- (9Ci) is a high-purity, non-proteinogenic amino acid derivative characterized by its specific stereochemistry at multiple chiral centers. This compound is a valuable chiral building block and intermediate in advanced organic synthesis, particularly for the development of pharmaceuticals and bioactive molecules. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require enantiomerically pure intermediates for asymmetric synthesis and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially protease inhibitors and other enzyme-targeted drugs.
• Asymmetric Catalysis: Used as a precursor or ligand in the development of chiral catalysts for stereoselective chemical transformations.
• Peptidomimetics & Drug Design: Incorporated into peptide analogs to enhance metabolic stability, bioavailability, and receptor selectivity.
• Agrochemical Research: Serves as a building block for creating novel, enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Biochemical Research: Utilized in studies of enzyme mechanisms, metabolic pathways, and as a standard for analytical method development.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex natural products and specialty chemicals requiring precise stereocontrol.

Basic Information

Product Name	D-Proline, 3-Hydroxy-5-Methyl-, (3R,5R)- (9Ci)
CAS No.	114717-08-7
Molecular Formula	C6H11NO3
Molecular Weight	145.16 g/mol
Synonyms	(3R,5R)-3-Hydroxy-5-methyl-D-proline; (2R,4R)-4-Hydroxy-2-methylpyrrolidine-2-carboxylic Acid; D-3-Hydroxy-5-methylproline; (3R,5R)-5-Methyl-3-hydroxyproline; (3R,5R)-3-Hydroxy-5-methylproline; (2R,4R)-2-Carboxy-4-hydroxy-2-methylpyrrolidine
EINECS	Contact for details

Quality Control

Our D-Proline, 3-Hydroxy-5-Methyl-, (3R,5R)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high enantiomeric purity and chemical identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.