Description

2-Hydroxy-2-(Trifluoromethyl)Butyric Acid is a specialized fluorinated organic acid featuring a hydroxyl group and a trifluoromethyl group on the same carbon atom, creating a unique steric and electronic profile. This structure makes it a valuable chiral building block and intermediate for synthesizing complex molecules with enhanced metabolic stability and lipophilicity. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by fine chemical manufacturers producing advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in protease inhibitors and other small molecule drugs where the trifluoromethyl group improves bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where its fluorinated structure can contribute to efficacy and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Production: Employed in the multi-step synthesis of complex fluorinated compounds for electronic materials and specialty polymers.
• Academic & Industrial Research: A valuable reagent for methodological studies in organic chemistry, exploring new fluorination reactions and synthetic pathways.

Basic Information

Product Name	2-Hydroxy-2-(Trifluoromethyl)Butyric Acid
CAS No.	114645-35-1
Molecular Formula	C5H7F3O3
Molecular Weight	172.10 g/mol
Synonyms	2-(Trifluoromethyl)-2-hydroxybutyric acid; α-Hydroxy-α-(trifluoromethyl)butyric acid; 2-Hydroxy-2-trifluoromethylbutanoic acid; 2-Trifluoromethyl-2-hydroxybutyric acid; 2-Hydroxy-2-(trifluoromethyl)butanoic acid; TFMBA; Butyric acid, 2-hydroxy-2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-2-(Trifluoromethyl)Butyric Acid is produced under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with detailed results from HPLC, NMR, and other relevant techniques. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.