Description

2-Hydroxy-2-Trifluoromethyl-Pent-4-Enoic Acid Methyl Ester is a high-value fluorinated building block essential for advanced organic synthesis. Its unique structure, featuring both a reactive hydroxyl group and a trifluoromethyl moiety, makes it a critical intermediate for introducing fluorine into target molecules, thereby enhancing their metabolic stability and lipophilicity. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated active pharmaceutical ingredients (APIs), particularly in protease inhibitor and CNS drug research.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides where the trifluoromethyl group improves biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty fluorinated polymers with unique surface properties and chemical resistance.
• Liquid Crystal & OLED Materials: Employed in the synthesis of fluorinated components for electronic displays and organic light-emitting diodes to optimize performance.
• Asymmetric Synthesis: Utilized as a chiral building block or auxiliary in stereoselective reactions to construct complex molecular architectures.
• Fluorine-19 NMR Spectroscopy: Can be used as a reference standard or probe in analytical chemistry due to its distinct fluorine signature.

Basic Information

Product Name	2-Hydroxy-2-Trifluoromethyl-Pent-4-Enoic Acid Methyl Ester
CAS No.	114645-32-8
Molecular Formula	C8H9F3O3
Molecular Weight	210.15 g/mol
Synonyms	Methyl 2-hydroxy-2-(trifluoromethyl)pent-4-enoate; 2-(Trifluoromethyl)-2-hydroxy-4-pentenoic acid methyl ester; 4-Pentenoic acid, 2-hydroxy-2-(trifluoromethyl)-, methyl ester; Methyl 2-hydroxy-2-trifluoromethyl-4-pentenoate; 2-Hydroxy-2-trifluoromethyl-4-pentenoic acid methyl ester; 2-Trifluoromethyl-2-hydroxy-4-pentenoic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of 2-Hydroxy-2-Trifluoromethyl-Pent-4-Enoic Acid Methyl Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by GC, HPLC, and NMR.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its properties, keep the container tightly sealed to minimize exposure to moisture and highly volatile loss. Incompatible with strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.