Description

(S)-1-Boc-3-Acetamidopyrrolidine CAS NO 114636-37-2 is a high-purity, chiral pyrrolidine derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a protected, stereochemically defined scaffold for constructing complex molecules with high enantiomeric purity. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other bioactive molecules.
• Peptidomimetics Research: Used to introduce constrained, proline-like structures into peptide backbones to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to construct stereogenic centers.
• Agrochemical Development: Building block for creating novel chiral herbicides, fungicides, and plant growth regulators.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: A fundamental component for custom synthesis projects requiring high stereochemical fidelity.

Basic Information

Item	Details
Product Name	(S)-1-Boc-3-Acetamidopyrrolidine
CAS No.	114636-37-2
Molecular Formula	C11H20N2O3
Molecular Weight	228.29 g/mol
Synonyms	(S)-1-(tert-Butoxycarbonyl)-3-acetamidopyrrolidine; (S)-3-Acetamido-1-Boc-pyrrolidine; (S)-N-(1-Boc-pyrrolidin-3-yl)acetamide; tert-Butyl (3S)-3-acetamidopyrrolidine-1-carboxylate; (S)-1-Boc-3-acetamidopyrrolidine; (S)-1-N-Boc-3-acetamidopyrrolidine; (S)-3-Acetamidopyrrolidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our (S)-1-Boc-3-Acetamidopyrrolidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure high enantiomeric excess (ee) and identity confirmation by spectroscopic methods. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.