Description

Meclizine N’’-Oxide is a key pharmaceutical intermediate and metabolite of the antihistamine drug Meclizine. This compound is of significant importance for research and development in the pharmaceutical industry, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of related active pharmaceutical ingredients (APIs). It serves as a critical building block for analytical reference standards and is essential for manufacturers and research institutions focused on neuropharmacology and antiemetic drug development.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis and development of Meclizine-based antiemetic and antivertigo medications.
• Metabolite Reference Standard: Used in analytical laboratories for the identification and quantification of Meclizine metabolites in biological matrices during pharmacokinetic and bioequivalence studies.
• Research Chemical: Employed in academic and industrial R&D for investigating the metabolic pathways, stability, and mechanism of action of antihistaminic drugs.
• Quality Control & Assurance: Serves as a high-purity standard for HPLC, LC-MS, and other analytical methods to ensure the purity and consistency of bulk Meclizine and its formulations.
• Chemical Synthesis: Utilized in organic synthesis for creating novel derivatives and analogs with potential therapeutic applications.

Basic Information

Product Name	Meclizine N’’-Oxide
CAS No.	114624-69-0
Molecular Formula	C25H27ClN2O2
Molecular Weight	422.95 g/mol
Synonyms	1-[(4-Chlorophenyl)(phenyl)methyl]-4-[(3-methylbenzyl)oxidanylidene]piperazine; Meclizine N-Oxide; Meclozine N-Oxide; Meclizine Oxide; Postafen N-Oxide; Bonamine N-Oxide; Antivert N-Oxide; 1-[(4-Chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine 1-oxide
EINECS	Contact for details

Quality Control

Our Meclizine N’’-Oxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis to ensure compliance with pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing all specifications and test results are provided to guarantee traceability and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.