Description

Fmoc-His(Fmoc)-Opfp CAS NO 114616-10-3 is a specialized, protected amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring high-purity building blocks to construct complex peptides with histidine residues. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic laboratories engaged in the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected building block for the controlled incorporation of histidine into peptide chains.
• Pharmaceutical Research: For the development and scale-up of novel therapeutic peptides targeting various diseases.
• Bioconjugation: Used in the synthesis of peptide-protein conjugates for antibody-drug conjugates (ADCs) or diagnostic probes.
• Combinatorial Chemistry: Serves as a valuable reagent in libraries for high-throughput screening of bioactive compounds.
• Biochemical Tool Development: Essential for creating custom peptides used as enzyme substrates, inhibitors, or receptor ligands in research.
• Process Development & Scale-Up: Supports the transition from laboratory-scale discovery to commercial manufacturing of peptide-based APIs.

Basic Information

Item	Detail
Product Name	Fmoc-His(Fmoc)-Opfp
CAS No.	114616-10-3
Molecular Formula	C43H30F5N3O7
Molecular Weight	795.71 g/mol
Synonyms	Fmoc-His(Fmoc)-OPfp; Nα-Fmoc-Nτ-Fmoc-L-histidine pentafluorophenyl ester; Fmoc-His(Fmoc)-OPfp ester; Fmoc-His(Fmoc)-O-Pfp; Fmoc-His(Fmoc)-OPfp; L-Histidine, Nα-[(-9-fluorenylmethoxy)carbonyl]-Nτ-[(-9-fluorenylmethoxy)carbonyl]-, pentafluorophenyl ester; Pentafluorophenyl Nα-Fmoc-Nτ-Fmoc-L-histidinate
EINECS	Contact for details

Quality Control

Every batch of Fmoc-His(Fmoc)-Opfp is produced and tested under strict quality management systems to ensure consistency and reliability for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, typically assessed via HPLC, NMR, and MS. Our quality commitment supports compliance with cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.