Description

H-α-Methyl-Ser(Tbu)-Oh is a protected, non-proteinogenic amino acid derivative, specifically an O-tert-butyl ether of α-methylserine. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, offering enhanced metabolic stability and conformational control. It is primarily utilized by pharmaceutical R&D and fine chemical manufacturers for the development of novel therapeutic agents and bioactive compounds.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Used to introduce constrained α-methylserine residues into peptide backbones to improve stability and biological activity.
• Solid-Phase Peptide Synthesis (SPPS): Serves as a protected amino acid building block for automated peptide assembly.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore new drug candidates.
• Bioconjugation: Can be used to create modified peptides for diagnostic or targeted delivery applications.
• Academic & Industrial R&D: A valuable reagent for chemical biology and organic synthesis research programs.

Basic Information

Product Name	H-α-Methyl-Ser(Tbu)-Oh
CAS No.	114396-73-5
Molecular Formula	C8H17NO3
Molecular Weight	175.23 g/mol
Synonyms	H-α-Me-Ser(OtBu)-OH; (S)-2-Amino-2-methyl-3-[(2-methylpropan-2-yl)oxy]propanoic acid; α-Methyl-L-serine tert-butyl ether; O-tert-Butyl-α-methylserine; (S)-2-Amino-2-methyl-3-(tert-butoxy)propanoic acid; H-α-MeSer(tBu)-OH; Fmoc-α-Me-Ser(OtBu)-OH precursor; Protected α-methylserine derivative
EINECS	Contact for details

Quality Control

Our H-α-Methyl-Ser(Tbu)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and synthesis. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.