Description

Fmoc-D-Dab(Fmoc)-Oh CAS NO 114360-56-4 is a protected amino acid derivative, specifically a di-Fmoc-protected derivative of D-2,4-diaminobutyric acid (D-Dab). This compound is a critical building block in the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, enabling the precise incorporation of a diamino acid residue with orthogonal side-chain protection. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who are developing therapeutic peptides, diagnostic agents, and biochemical tools that require high-purity, sequence-specific amino acid precursors.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the automated synthesis of peptides containing D-2,4-diaminobutyric acid residues.
• Pharmaceutical Research & Development: Used in the discovery and production of novel peptide-based drugs, including antimicrobial peptides, hormone analogs, and targeted therapeutics.
• Peptidomimetic Design: Serves as a scaffold for creating modified peptides with enhanced stability, bioavailability, or receptor binding affinity.
• Bioconjugation and Labeling: The free amino group (after selective deprotection) can be utilized for coupling with fluorescent dyes, biotin, or other functional molecules.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse libraries of compounds for high-throughput screening.
• Academic & Institutional Research: Fundamental research in biochemistry, structural biology, and medicinal chemistry exploring protein-protein interactions and enzyme mechanisms.

Basic Information

Product Name	Fmoc-D-Dab(Fmoc)-Oh
CAS No.	114360-56-4
Molecular Formula	C34H30N2O6
Molecular Weight	562.61 g/mol
Synonyms	Fmoc-D-Dab(Fmoc)-OH; Nα,Nω-Bis(9-fluorenylmethoxycarbonyl)-D-2,4-diaminobutyric acid; D-Dab(Boc)-OH (common precursor name); (2R)-2,4-Bis{[(9H-fluoren-9-yl)methoxy]carbonyl}aminobutanoic acid; Fmoc-D-Dab(Fmoc); D-2,4-Diaminobutyric acid, Nα,Nω-bis(9-fluorenylmethyloxycarbonyl)-; Fmoc-D-Dab(2-Fmoc)-OH; Protected D-Diaminobutyric Acid
EINECS	Contact for details

Quality Control

Our Fmoc-D-Dab(Fmoc)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We support compliance with cGMP, ISO, and other relevant regulatory frameworks for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0% (Area %)
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.