Description

3-(2-Bromopropanoyl)-4,4-Dimethyl-1,3-Oxazolidin-2-One is a specialized chiral oxazolidinone derivative, a crucial building block in modern asymmetric synthesis. Its primary value lies in its role as a highly effective chiral auxiliary, enabling the stereoselective formation of carbon-carbon bonds, which is fundamental for producing enantiomerically pure pharmaceuticals and fine chemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require high-purity intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral auxiliary in the asymmetric synthesis of active pharmaceutical ingredients (APIs), particularly for constructing complex stereocenters.
• Agrochemical Synthesis: Used in the research and development of enantiomerically pure herbicides, fungicides, and insecticides.
• Asymmetric Aldol Reactions: Facilitates highly diastereoselective aldol condensations, a cornerstone reaction in organic synthesis.
• Natural Product Synthesis: Employed in the total synthesis of complex natural products with multiple chiral centers.
• Process Chemistry & Scale-up: Serves as a reliable reagent for developing scalable, cost-effective manufacturing processes for chiral molecules.
• Academic & Industrial R&D: A valuable tool for methodological development in synthetic organic chemistry laboratories.

Basic Information

Product Name	3-(2-Bromopropanoyl)-4,4-Dimethyl-1,3-Oxazolidin-2-One
CAS No.	114341-88-7
Molecular Formula	C8H12BrNO3
Molecular Weight	250.09 g/mol
Synonyms	(4R)-3-[(2S)-2-Bromopropanoyl]-4,4-dimethyl-1,3-oxazolidin-2-one; (4R)-3-[(2S)-2-Bromopropionyl]-4,4-dimethyl-2-oxazolidinone; (S)-2-Bromopropionic Acid (R)-4,4-Dimethyl-2-oxazolidinone Ester; N-((S)-2-Bromopropionyl)-4,4-dimethyloxazolidin-2-one; Evans Chiral Auxiliary Bromide Derivative; 2-Bromopropionic Acid Oxazolidinone Amide; Contact for details on additional synonyms.
EINECS	Contact for details

Quality Control

Our 3-(2-Bromopropanoyl)-4,4-Dimethyl-1,3-Oxazolidin-2-One is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as chiral purity (enantiomeric excess), chemical assay, and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (ee)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.