Description

n-Desmethyl cis-Terbinafine is a key pharmaceutical intermediate and metabolite of the antifungal agent Terbinafine. This compound is of significant importance for research and development in the synthesis of novel antifungal agents and for conducting detailed metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, analytical reference standard producers, and manufacturers of active pharmaceutical ingredients (APIs) who require high-purity building blocks for advanced synthesis.

Application

• Pharmaceutical Intermediate: A critical building block in the research and synthesis of new antifungal compounds and analogs.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies to understand the metabolism and pharmacokinetics of Terbinafine.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the development and scale-up processes for antifungal APIs.
• Biochemical Research: Employed in in-vitro studies to investigate the mechanism of action and resistance profiles of allylamine antifungals.
• Quality Control & Testing: Essential for pharmaceutical quality assurance laboratories to identify and quantify related substances in Terbinafine drug products.

Basic Information

Product Name	n-Desmethyl cis-Terbinafine
CAS No.	114311-72-7
Molecular Formula	C₂₀H₂₇N
Molecular Weight	281.44 g/mol
Synonyms	(2E)-N,6,6-Trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine; (E)-N-Methyl-N-((1-naphthyl)methyl)-6,6-dimethyl-2-hepten-4-yn-1-amine; cis-n-Desmethyl Terbinafine; Terbinafine Impurity; Terbinafine Related Compound; Terbinafine Metabolite; (E)-N,6,6-Trimethyl-N-(1-naphthylmethyl)-2-hepten-4-yn-1-amine
EINECS	Contact for details

Quality Control

Our n-Desmethyl cis-Terbinafine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical research and development. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect the integrity of the material.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.