Description

Corticotropen-Releasing Hormone, Nle(21,38)-Arg(36)- CAS NO 114308-86-0 is a synthetic, high-purity analog of the endogenous corticotropin-releasing hormone (CRH). This compound is engineered for enhanced stability and biological activity, making it a critical reagent in advanced neuroendocrine and pharmacological research. It is essential for scientists and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require precise and reliable peptides for drug discovery, assay development, and biochemical studies.

Application

• Neuroendocrine Research: Used as a standard or tool compound to study the hypothalamic-pituitary-adrenal (HPA) axis, stress response mechanisms, and related disorders.
• Pharmaceutical R&D: Serves as a key intermediate or reference material in the development of novel therapeutics targeting CRH receptors for conditions like anxiety, depression, and Cushing's syndrome.
• Diagnostic Assay Development: Employed in the calibration and validation of immunoassays (e.g., ELISA) and other bioanalytical methods designed to measure CRH levels.
• Cell Signaling Studies: Applied in vitro to stimulate CRH receptors and investigate downstream intracellular signaling pathways and gene expression.
• Peptide Chemistry & Conjugation: Acts as a base structure for further chemical modification, labeling, or conjugation in probe development.

Basic Information

Product Name	Corticotropen-Releasing Hormone, Nle(21,38)-Arg(36)-
CAS No.	114308-86-0
Molecular Formula	C207H340N64O57S2
Molecular Weight	4690.4 g/mol
Synonyms	CRH (Nle(21,38), Arg(36)); CRH, Nle(21,38)-Arg(36)-; hCRH (21-38)-Nle,36-Arg; Corticotropin-Releasing Factor Analog; Corticoliberin analog; Sauvagine-related peptide; CRF (human) fragment 21-38, Nle(21,38)-Arg(36)-; Stresscopin-related peptide
EINECS	Contact for details

Quality Control

Our Corticotropen-Releasing Hormone, Nle(21,38)-Arg(36)- is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide comprehensive Certificates of Analysis (COA) with detailed specifications to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by AAA)
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 8.0%
Acetate Content (HPLC)	≤ 15.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.