Description

2,3,6-Trifluorophenylacetic Acid is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its value lies in the unique electronic and steric properties imparted by the specific trifluoro substitution pattern, which is critical for modulating the biological activity and physicochemical characteristics of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, as well as by manufacturers of specialty materials and liquid crystals.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance lipophilicity, metabolic stability, and binding affinity.
• Liquid Crystal Materials: Serves as a precursor for fluorinated mesogens, improving the dielectric anisotropy and thermal stability of display components.
• Organic Light-Emitting Diodes (OLEDs): Employed in the synthesis of electron-transport or host materials for more efficient and durable electronic displays.
• Peptide Mimetics & Bio-conjugation: The carboxylic acid group allows for coupling to create non-natural amino acids or for labeling biomolecules in probe development.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.

Basic Information

Product Name	2,3,6-Trifluorophenylacetic Acid
CAS No.	114152-23-7
Molecular Formula	C8H5F3O2
Molecular Weight	190.12 g/mol
Synonyms	(2,3,6-Trifluorophenyl)acetic Acid; 2-(2,3,6-Trifluorophenyl)acetic Acid; α-(2,3,6-Trifluorophenyl)acetic Acid; 2,3,6-Trifluorobenzeneacetic Acid; NSC 405124; 114152-23-7 (CAS); TFPA; 2,3,6-Trifluoro-α-toluic Acid
EINECS	Contact for details

Quality Control

Our 2,3,6-Trifluorophenylacetic Acid is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.