Description

2,3,6-Trifluorobenzyl Chloride is a versatile fluorinated aromatic building block essential for advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms and a reactive benzyl chloride group, enabling the precise construction of complex molecules with tailored properties. This intermediate is critically needed by R&D and production teams in the pharmaceutical, agrochemical, and specialty materials industries for developing new active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drugs where fluorine atoms enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, leveraging the fluorine substituents to improve efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, where fluorine improves thermal stability and optical properties.
• Polymer & Resin Modification: Employed to introduce fluorinated benzyl groups into polymer chains, enhancing material characteristics like chemical resistance, weatherability, and surface energy.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed reactions (e.g., Suzuki, Heck) for creating complex biaryl structures common in many advanced chemicals.
• Ligand & Catalyst Development: Used to synthesize specialized fluorinated ligands for catalysis and molecular recognition applications.

Basic Information

Product Name	2,3,6-Trifluorobenzyl Chloride
CAS No.	114152-20-4
Molecular Formula	C7H4ClF3
Molecular Weight	192.55 g/mol
Synonyms	(2,3,6-Trifluorophenyl)methyl Chloride; 1-(Chloromethyl)-2,3,6-trifluorobenzene; α-Chloro-2,3,6-trifluorotoluene; 2,3,6-Trifluoro-benzylchloride; 2,3,6-Trifluorobenzylchloride; Benzene, 1-(chloromethyl)-2,3,6-trifluoro-; 2,3,6-Trifluorophenylmethyl Chloride
EINECS	Contact for details

Quality Control

Our 2,3,6-Trifluorobenzyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC/GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.