Description

[1S-(1α,2β,5α)]-5-Methyl-2-(1-Methylethyl)Cyclohexyl β-D-Glucopyranosiduronic Acid is a high-purity, stereochemically defined glucuronide conjugate, a crucial metabolite and reference standard in modern pharmaceutical research and development. Its primary value lies in enabling precise pharmacokinetic and metabolic studies, particularly for compounds containing the menthol or related terpene scaffolds. This compound is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and advanced chemical synthesis sectors who require definitive analytical standards for metabolite identification and quantification.

Application

• Pharmaceutical Reference Standard: Serves as a certified primary standard for the quantification of menthol glucuronide metabolites in bioanalytical assays (plasma, urine).
• Drug Metabolism and Pharmacokinetics (DMPK): Critical for in vitro and in vivo studies to understand the metabolic fate, clearance pathways, and bioavailability of parent drug compounds.
• Toxicology Studies: Used to investigate the detoxification and excretion pathways of specific terpenes and related synthetic molecules.
• Analytical Method Development: Employed for calibrating and validating HPLC, LC-MS, and GC-MS methods in regulatory-compliant laboratories.
• Biochemical Research: Acts as a substrate or inhibitor in studies of UDP-glucuronosyltransferase (UGT) enzyme activity and specificity.
• Process Chemistry: Can be used as an intermediate or a model compound in the synthesis of more complex glucuronidated molecules.

Basic Information

Item	Details
Product Name	[1S-(1α,2β,5α)]-5-Methyl-2-(1-Methylethyl)Cyclohexyl β-D-Glucopyranosiduronic Acid
CAS No.	114127-73-0
Molecular Formula	C16H28O7
Molecular Weight	332.39 g/mol
Synonyms	(-)-Menthol β-D-Glucuronide; L-Menthol Glucuronide; (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl β-D-Glucopyranosiduronic Acid; Menthol Glucuronide; Menthol β-D-Glucopyranosiduronic Acid; 5-Methyl-2-(1-methylethyl)cyclohexyl β-D-Glucopyranosiduronic Acid, [1S-(1α,2β,5α)]-
EINECS	Contact for details

Quality Control

Every batch of [1S-(1α,2β,5α)]-5-Methyl-2-(1-Methylethyl)Cyclohexyl β-D-Glucopyranosiduronic Acid is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support its use as a reference material, including identity confirmation by spectroscopic methods and purity assessment by chromatographic techniques. A detailed Certificate of Analysis (COA) specifying batch-specific results for identity, assay, and impurities is supplied with each shipment, ensuring traceability and compliance with internal and regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.