Description

Fmoc-Leu-Odhbt CAS NO 114119-83-4 is a specialized, activated ester derivative of the amino acid leucine, protected with a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), offering enhanced coupling efficiency and reduced racemization risk. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and bioconjugates.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key activated amino acid derivative for the efficient, sequential assembly of peptide chains.
• Pharmaceutical Research & Development: For the synthesis of peptide-based drug candidates, hormones, and therapeutic agents.
• Bioconjugation: Used to introduce leucine residues or Fmoc-protected handles into proteins, antibodies, or other biomolecules.
• Combinatorial Chemistry: A valuable reagent in libraries for high-throughput screening of bioactive peptides.
• Academic Research: For studying peptide structure-activity relationships and developing new synthetic methodologies.
• Production of Custom Peptides: By CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) for client projects.

Basic Information

Product Name	Fmoc-Leu-Odhbt
CAS No.	114119-83-4
Molecular Formula	C31H30N4O6
Molecular Weight	554.59 g/mol
Synonyms	Fmoc-L-leucine 3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl ester; N-(9-Fluorenylmethoxycarbonyl)-L-leucine 3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl ester; Fmoc-Leu-ODhbt; Fmoc-Leu-OBt; Fmoc-L-Leu-ODhbt; Nα-Fmoc-leucine Dhbt ester; Leucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl ester
EINECS	Contact for details

Quality Control

Our Fmoc-Leu-Odhbt is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is analyzed via HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability and performance. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.