Description

Atrial Natriuretic Factor (1-98) is a synthetic polypeptide fragment corresponding to the biologically active core of the endogenous human cardiac hormone. This high-purity peptide is critical for cardiovascular and renal research, serving as a key reference standard and active pharmaceutical ingredient. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic manufacturers focused on hypertension, heart failure, and natriuresis mechanisms.

Application

• Pharmaceutical Reference Standard: Used for the calibration and validation of analytical methods (HPLC, MS) in drug development and quality control laboratories.
• Biochemical Research: Essential for in vitro and in vivo studies investigating the ANP receptor (NPR-A) signaling pathway, vasodilation, and sodium excretion.
• Diagnostic Kit Development: Serves as a critical antigen or calibrator in the production of immunoassay kits for measuring ANP levels in clinical samples.
• Preclinical Studies: Employed in animal models to study the therapeutic potential of ANP analogs for treating cardiovascular and renal diseases.
• Cell Culture & Signal Transduction: Used to stimulate cellular responses in cultured cells to study second messenger systems like cGMP.

Basic Information

Product Name	Atrial Natriuretic Factor (1-98)
CAS No.	114101-49-4
Molecular Formula	C433H701N131O126S8
Molecular Weight	~10.8 kDa
Synonyms	ANF (1-98); Atrial Natriuretic Peptide (1-98); ANP (1-98); Cardionatrin (1-98); Atriopeptin (1-98); Auriculin A (1-98); Atrial Natriuretic Polypeptide; α-ANP (1-98)
EINECS	Contact for details

Quality Control

Every batch of Atrial Natriuretic Factor (1-98) is manufactured and tested under strict quality systems. Our products undergo rigorous analytical characterization, including reverse-phase HPLC, mass spectrometry (MS), and amino acid analysis, to ensure identity, purity, and biological activity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by ESI-TOF or MALDI-TOF
Purity (HPLC)	≥ 95% (Area Percent)
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Biological Activity	Determined by in vitro cGMP assay (Reported per COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.