Description

5-(2-Fluorophenyl)-4-Methyl-4H-1,2,4-Triazole-3-Thiol is a high-purity, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because its unique triazole-thiol core, functionalized with a fluorophenyl group, provides a versatile scaffold for constructing molecules with tailored biological and material properties. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry, drug discovery, and the development of novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, due to the fluorine atom's ability to modulate bioavailability and metabolic stability.
• Agrochemical Research: Used in the development of new-generation fungicides, herbicides, and insecticides, where the triazole-thiol moiety can act as a potent bioactive core.
• Material Science Precursor: Serves as a monomer or functional additive in the synthesis of specialized polymers, ligands for metal-organic frameworks (MOFs), or corrosion inhibitors.
• Chemical Biology Probe: Utilized in biochemical research to develop enzyme inhibitors or fluorescent probes, leveraging the reactive thiol group for conjugation.
• Coordination Chemistry: Acts as a versatile ligand for transition metals, forming complexes with potential catalytic or luminescent properties.

Basic Information

Product Name	5-(2-Fluorophenyl)-4-Methyl-4H-1,2,4-Triazole-3-Thiol
CAS No.	114058-90-1
Molecular Formula	C9H8FN3S
Molecular Weight	209.24 g/mol
Synonyms	4-Methyl-5-(2-fluorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione; 5-(2-Fluorophenyl)-4-methyl-4H-1,2,4-triazole-3-thiol; 3H-1,2,4-Triazole-3-thione, 4-methyl-5-(2-fluorophenyl)-2,4-dihydro-; 4-Methyl-5-(o-fluorophenyl)-4H-1,2,4-triazole-3-thiol; 2-Fluorophenyl-4-methyl-1,2,4-triazole-3-thiol
EINECS	Contact for details

Quality Control

Our 5-(2-Fluorophenyl)-4-Methyl-4H-1,2,4-Triazole-3-Thiol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP principles and reliable supply chain management ensures material integrity from production to delivery.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening containers to minimize degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.