Description

Pyrrolidine, 1-(2,3,3,3-Tetrafluoro-1-Oxopropyl)- (9Ci) is a specialized fluorinated pyrrolidine derivative, a key building block in advanced organic synthesis. Its unique structure, featuring a tetrafluoropropanoyl moiety, makes it a valuable precursor for introducing fluorinated motifs into complex molecules, which is critical for modulating the physicochemical and biological properties of target compounds. This high-purity intermediate is essential for research and development in the pharmaceutical and agrochemical industries, where precise fluorination is required to enhance metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: Serves as a critical synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for introducing fluorinated groups to improve drug-like properties.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where fluorination can increase compound stability, potency, and environmental persistence.
• Material Science Research: Acts as a monomer or functionalizing agent in the development of specialty polymers and advanced materials with unique surface characteristics or stability.
• Ligand and Catalyst Development: Employed in the synthesis of novel chiral ligands or organocatalysts for asymmetric synthesis, leveraging the pyrrolidine core.
• Fluorinated Compound Library Synthesis: A key reagent for medicinal and combinatorial chemists building diverse libraries of fluorinated compounds for high-throughput screening.
• Academic and Industrial R&D: Utilized in research laboratories for methodological development and exploring new reactions involving fluorinated building blocks.

Basic Information

Item	Detail
Product Name	Pyrrolidine, 1-(2,3,3,3-Tetrafluoro-1-Oxopropyl)- (9Ci)
CAS No.	113985-87-8
Molecular Formula	C7H9F4NO
Molecular Weight	199.15 g/mol
Synonyms	1-(2,3,3,3-Tetrafluoropropanoyl)pyrrolidine; 2,3,3,3-Tetrafluoro-1-(pyrrolidin-1-yl)propan-1-one; N-(2,3,3,3-Tetrafluoropropanoyl)pyrrolidine; Tetrafluoropropanoyl pyrrolidine; Pyrrolidine, 1-(tetrafluoropropionyl)-; 1-(Perfluoroethyl)carbonylpyrrolidine; Fluorinated pyrrolidine amide; N-Pyrrolidyl-2,3,3,3-tetrafluoropropanamide
EINECS	Contact for details

Quality Control

Our production of Pyrrolidine, 1-(2,3,3,3-Tetrafluoro-1-Oxopropyl)- (9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including NMR (¹H, ¹³C, ¹⁹F), HPLC, GC, and Karl Fischer titration, to verify identity, potency, and impurity profiles. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support compliance with global regulatory frameworks, and custom synthesis to meet specific pharma-grade or research-grade specifications is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after initial opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.