Description

2-Methyl-4-[(3-Trifluoromethyl)Phenyl]-1-Butene is a specialized fluorinated organic intermediate featuring a reactive terminal alkene and a trifluoromethylphenyl group. This unique structure makes it a valuable building block for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where the introduction of fluorine atoms is critical for modulating biological activity and physicochemical properties. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory diseases, where the trifluoromethyl group enhances metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in creating advanced herbicides and fungicides, leveraging the fluorine moiety to improve efficacy, photostability, and environmental persistence of the final active ingredient.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated mesogens and electron-transport materials, contributing to improved performance in display and lighting technologies.
• Polymer Modification: Employed to introduce fluorinated side chains into polymers, enhancing properties such as chemical resistance, thermal stability, and surface characteristics for specialty coatings and high-performance plastics.
• Cross-Coupling Reactions: The alkene functionality allows for use in Heck reactions and other palladium-catalyzed cross-couplings to create complex, fluorinated biaryl structures.
• Fluorine-18 Radiochemistry: Potential precursor for the development of Positron Emission Tomography (PET) tracers in medical imaging research.

Basic Information

Product Name	2-Methyl-4-[(3-Trifluoromethyl)Phenyl]-1-Butene
CAS No.	113947-87-8
Molecular Formula	C12H13F3
Molecular Weight	214.23 g/mol
Synonyms	1-Butene, 2-methyl-4-[3-(trifluoromethyl)phenyl]-; 4-(3-Trifluoromethylphenyl)-2-methyl-1-butene; 2-Methyl-4-(3-trifluoromethylphenyl)but-1-ene; 3-Trifluoromethyl-β,β-dimethylstyrene; α,β-Dimethyl-3-(trifluoromethyl)styrene; (3-Trifluoromethylphenyl)isobutylethylene
EINECS	Contact for details

Quality Control

Every batch of 2-Methyl-4-[(3-Trifluoromethyl)Phenyl]-1-Butene is produced and analyzed under strict quality management protocols. We provide comprehensive analytical data to ensure consistency and purity for your critical synthetic applications. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles by GC/HPLC are available for each lot. Our quality systems support development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is sensitive to strong bases and fluorides; keep away from incompatible materials. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.