Description

Acetyldithio-Coenzyme A is a specialized, high-purity biochemical reagent that serves as a critical substrate and inhibitor in the study of key metabolic pathways. This compound is essential for researchers and manufacturers requiring precise tools for investigating enzyme kinetics, particularly those involving coenzyme A derivatives and acyltransferase activity. It is primarily utilized by the pharmaceutical, biotechnology, and academic research sectors for drug discovery, metabolic research, and biochemical assay development.

Application

• Enzyme Mechanism Studies: Used as a substrate or competitive inhibitor for investigating the activity of enzymes like carnitine acetyltransferase and other acyl-CoA utilizing enzymes.
• Metabolic Pathway Research: A key tool in studying fatty acid metabolism, cholesterol synthesis, and mitochondrial energy production pathways.
• Pharmaceutical Development: Employed in high-throughput screening (HTS) assays to identify and characterize potential therapeutic compounds targeting metabolic disorders.
• Biochemical Assay Standard: Serves as a critical reference standard in quantitative analytical methods such as HPLC and mass spectrometry for CoA-derivative analysis.
• Academic Research: Fundamental for university and institutional labs focused on biochemistry, molecular biology, and cellular metabolism.

Basic Information

Product Name	Acetyldithio-Coenzyme A
CAS No.	113947-51-6
Molecular Formula	C23H38N7O17P3S2
Molecular Weight	869.62 g/mol
Synonyms	Acetyl-CoA disulfide; S-Acetyldithio-CoA; Acetyl coenzyme A disulfide; Acetyl-CoA thioester disulfide; Acetyl-S-CoA disulfide; 3'-dephospho-CoA S-acetyl disulfide; Acetylated Coenzyme A disulfide
EINECS	Contact for details

Quality Control

Our Acetyldithio-Coenzyme A is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for biochemical reagents, and specifications can be tailored to meet specific research-grade or GMP-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.