Description

(2R,4S)-3-Benzoyl-4-Methyl-2-Phenyl-5-Oxazolidinone is a high-purity chiral oxazolidinone derivative, widely recognized as a versatile Evans-type chiral auxiliary in asymmetric synthesis. Its primary value lies in enabling the stereoselective construction of complex molecules, ensuring high enantiomeric excess in critical synthetic steps. This compound is essential for research chemists and process development scientists in the pharmaceutical and fine chemical industries, particularly for the production of active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• As a chiral auxiliary in Evans aldol reactions for the asymmetric synthesis of β-hydroxy carbonyl compounds.
• For the stereocontrolled alkylation of enolates in the synthesis of α-substituted carboxylic acid derivatives.
• In the preparation of non-proteinogenic amino acids and other chiral building blocks for peptide mimetics and drug candidates.
• As a key reagent in academic and industrial R&D for methodology development in organic and medicinal chemistry.
• For the synthesis of complex natural products and pharmaceutical intermediates requiring high optical purity.
• In process chemistry for scaling up asymmetric transformations under GMP or non-GMP conditions.

Basic Information

Product Name	(2R,4S)-3-Benzoyl-4-Methyl-2-Phenyl-5-Oxazolidinone
CAS No.	113806-28-3
Molecular Formula	C17H15NO3
Molecular Weight	281.31 g/mol
Synonyms	(4S)-3-Benzoyl-4-Methyl-2-Phenyl-1,3-Oxazolidin-5-one; (2R,4S)-3-Benzoyl-4-Methyl-2-Phenyl-5-Oxazolidinone; Evans Auxiliary; (4S)-4-Methyl-3-benzoyl-2-phenyl-1,3-oxazolidin-5-one; (4S)-4-Methyl-3-benzoyl-2-phenyloxazolidin-5-one; (S)-4-Methyl-3-benzoyl-2-phenyloxazolidin-5-one; (4S)-4-Methyl-2-phenyl-3-(phenylcarbonyl)-5-oxazolidinone
EINECS	Contact for details

Quality Control

Our (2R,4S)-3-Benzoyl-4-Methyl-2-Phenyl-5-Oxazolidinone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard spectroscopic methods for identity confirmation, to ensure compliance with high-purity research and development standards. Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.