Description

(2S,3R)-3-Hydroxy-2-{[(4-Methoxyphenyl)Sulfonyl]Amino}Butanoic Acid is a high-purity, non-proteinogenic amino acid derivative featuring a p-methoxybenzenesulfonyl (PMBS) protecting group on the amine and a free carboxylic acid. This compound matters as a critical chiral building block and advanced pharmaceutical intermediate, enabling the synthesis of complex molecules with precise stereochemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly peptidomimetics, enzyme inhibitors, and other bioactive compounds where stereochemical integrity is paramount.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially for protease inhibitors and other targeted therapies.
• Peptidomimetic Research: Used to incorporate modified amino acid residues into peptide backbones to enhance metabolic stability, bioavailability, and receptor selectivity.
• Chemical Biology & Proteomics: Employed as a tool compound or a precursor for activity-based probes to study enzyme function and mechanism.
• Asymmetric Synthesis: Utilized as a starting material or auxiliary in stereoselective reactions to construct complex molecular architectures.
• Medicinal Chemistry: Provides a scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Academic & Industrial R&D: Fundamental research into new synthetic methodologies and the exploration of novel chemical space for bioactive molecules.

Basic Information

Product Name	(2S,3R)-3-Hydroxy-2-{[(4-Methoxyphenyl)Sulfonyl]Amino}Butanoic Acid
CAS No.	113793-31-0
Molecular Formula	C11H15NO6S
Molecular Weight	289.30 g/mol
Synonyms	(2S,3R)-3-Hydroxy-2-[(4-methoxybenzenesulfonyl)amino]butanoic acid; (2S,3R)-2-[(4-Methoxyphenyl)sulfonyl]amino-3-hydroxybutyric acid; L-threonine, N-[(4-methoxyphenyl)sulfonyl]-; PMBS-Threonine; N-(p-Methoxybenzenesulfonyl)-L-threonine; N-PMBS-L-threonine; (2S,3R)-N-(4-Methoxybenzenesulfonyl)threonine; 2-[(4-Methoxyphenyl)sulfonyl]amino-3-hydroxybutanoic acid (stereochemistry specified)
EINECS	Contact for details

Quality Control

Our (2S,3R)-3-Hydroxy-2-{[(4-Methoxyphenyl)Sulfonyl]Amino}Butanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to confirm stereochemical purity and identity. We provide comprehensive Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.