Description

Amca-Nhs is a specialized, high-purity chemical intermediate widely used in advanced organic synthesis and bioconjugation chemistry. This compound is valued for its role as an activated ester, enabling efficient and selective coupling reactions under mild conditions. It is an essential reagent for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors developing novel therapeutics, probes, and biomaterials.

Application

• Peptide Synthesis: Key intermediate for the formation of amide bonds in solid-phase and solution-phase peptide synthesis.
• Antibody-Drug Conjugate (ADC) Development: Used to link cytotoxic payloads to monoclonal antibodies via stable linker systems.
• Protein Labeling & Modification: Facilitates the site-specific conjugation of fluorophores, biotin, or other functional groups to proteins and antibodies.
• Biomaterial Functionalization: Employed to modify surfaces of polymers, nanoparticles, or hydrogels with bioactive ligands for tissue engineering and biosensing.
• Small Molecule Prodrug Synthesis: Acts as a linker in the design of prodrugs for targeted drug delivery and controlled release.
• Diagnostic Reagent Manufacturing: Integral in producing labeled antigens, haptens, and other components for immunoassay kits.

Basic Information

Product Name	Amca-Nhs
CAS No.	113721-87-2
Molecular Formula	C18H17N3O6
Molecular Weight	371.35 g/mol
Synonyms	7-Amino-4-methylcoumarin-3-acetic acid N-hydroxysuccinimide ester; AMCA-OSu; AMCA-NHS ester; 3-((2,5-Dioxopyrrolidin-1-yl)oxy)-3-oxopropyl)-7-(dimethylamino)-2-oxo-2H-chromene-4-carboxylic acid; 7-(Dimethylamino)-4-methyl-2-oxo-2H-chromene-3-acetic acid N-succinimidyl ester; AMCA-X, SE; AMCA succinimidyl ester
EINECS	Contact for details

Quality Control

Our Amca-Nhs is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and loss on drying. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.