Description

n-Pivaloyloxymethylchlorpromazine CAS NO 113611-35-1 is a chemically modified prodrug derivative of the classic antipsychotic agent chlorpromazine, designed for enhanced stability and bioavailability. This compound is of significant interest in advanced pharmaceutical research and development, particularly for creating novel drug delivery systems and investigating sustained-release formulations. It serves as a critical intermediate for medicinal chemists and R&D teams in the pharmaceutical and fine chemical industries focused on neuropharmacology and prodrug technology.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel antipsychotic prodrug formulations.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to modify the pharmacokinetic profile of phenothiazine derivatives.
• Drug Delivery System Development: Employed in the design of lipophilic prodrugs aimed at improving blood-brain barrier penetration and controlled release.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Tool Compound: Utilized in preclinical research to study the metabolism and activation pathways of prodrugs targeting neurological receptors.

Basic Information

Product Name	n-Pivaloyloxymethylchlorpromazine
CAS No.	113611-35-1
Molecular Formula	C23H29ClN2O2S
Molecular Weight	432.99 g/mol
Synonyms	Chlorpromazine Pivaloyloxymethyl Prodrug; POM-Chlorpromazine; 2-Chloro-10-[3-(dimethylamino)propyl]-10H-phenothiazine Pivaloyloxymethyl Derivative; N-Pivaloyloxymethyl Chlorpromazine; 113611-35-1; Chlorpromazine POM Ester; Pivaloyloxymethyl Chlorpromazine
EINECS	Contact for details

Quality Control

Our n-Pivaloyloxymethylchlorpromazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.