Description

m-Nisoldipine CAS NO 113578-26-0 is a high-purity pharmaceutical intermediate and research chemical belonging to the dihydropyridine class of calcium channel blockers. It serves as a critical building block in the synthesis and development of advanced cardiovascular drugs targeting hypertension and angina. This compound is essential for pharmaceutical R&D laboratories, API manufacturers, and academic institutions engaged in cardiovascular research and novel drug formulation.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of Nisoldipine and related dihydropyridine calcium channel blocker active pharmaceutical ingredients (APIs).
• Research & Development: Key reference standard and starting material for medicinal chemistry programs focused on cardiovascular disease.
• Analytical Standard: Used as a high-purity standard in HPLC, LC-MS, and other analytical methods for quality control and pharmacokinetic studies.
• Process Chemistry: Employed in scale-up and optimization of manufacturing processes for finished dosage forms.
• Academic Research: Utilized in university and institutional labs for studying calcium channel physiology and drug-receptor interactions.

Basic Information

Product Name	m-Nisoldipine
CAS No.	113578-26-0
Molecular Formula	C20H24N2O6
Molecular Weight	388.42 g/mol
Synonyms	3-Methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 3-Methyl 5-isobutyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; Methyl isobutyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; Nisoldipine Impurity; Nisoldipine Related Compound; Bay k 5552 Intermediate; Dihydropyridine Derivative
EINECS	Contact for details

Quality Control

Our m-Nisoldipine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis to ensure it meets stringent specifications for pharmaceutical use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with in-house standards that align with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.