Description

Fosinoprilat Acyl-β-D-Glucuronide is a key metabolite of the active angiotensin-converting enzyme (ACE) inhibitor, fosinoprilat. This compound is of significant importance in pharmaceutical research and development, particularly for metabolism and pharmacokinetic studies. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in bioanalytical method development, drug metabolism and pharmacokinetics (DMPK), and regulatory compliance testing.

Application

• Reference Standard for Bioanalysis: Serves as a critical certified reference material (CRM) for the quantification of fosinoprilat and its metabolites in biological matrices using LC-MS/MS or HPLC.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, clearance mechanisms, and excretion profiles of the prodrug fosinopril sodium.
• Pharmacological Research: Used in studies to understand the activity and disposition of the glucuronidated metabolite compared to the parent active drug.
• Impurity Profiling and Method Development: Acts as a known impurity or degradation product standard for the stability testing and analytical method validation of fosinopril-based formulations.
• Regulatory Submissions: Supports regulatory filings (e.g., for FDA, EMA) by providing definitive characterization data for a major human metabolite.

Basic Information

Item	Details
Product Name	Fosinoprilat Acyl-β-D-Glucuronide
CAS No.	113411-09-9
Molecular Formula	C30H45NO11P
Molecular Weight	626.66 g/mol
Synonyms	(4S)-4-Cyclohexyl-1-[[(2-methyl-1-propanoyloxypropoxy)(4-phenylbutyl)phosphinyl]acetyl]-L-proline β-D-Glucopyranosiduronic Acid; Fosinoprilat 1-β-O-Acyl Glucuronide; Fosinopril Acyl Glucuronide; Fosinoprilat Glucuronide; SQ 27,519; SQ-27519; SQ27519; Fosinopril Metabolite
EINECS	Contact for details

Quality Control

Our Fosinoprilat Acyl-β-D-Glucuronide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided, documenting identity, purity, and all critical quality attributes to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.