Description

3-Chloro-2-Iodo-1,1,1-Trifluoropropane is a specialized halogenated fluorocarbon building block of significant interest in advanced organic synthesis. This compound matters for its unique reactivity profile, offering a trifluoromethyl group alongside chlorine and iodine substituents, which enables precise functionalization and the introduction of fluorine atoms into target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing novel active pharmaceutical ingredients (APIs), particularly those requiring a trifluoromethyl group for improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides where fluorine substitution is critical for activity.
• Advanced Material Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and electronic materials.
• Fluorination Reagent: Acts as a source of the -CF3 moiety in nucleophilic or radical fluorination reactions under controlled conditions.
• Cross-Coupling Substrate: The iodine and chlorine atoms provide orthogonal handles for sequential metal-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi).
• Organic Synthesis Research: A versatile reagent in academic and industrial laboratories for methodology development and exploring new reaction pathways involving polyhalogenated compounds.

Basic Information

Product Name	3-Chloro-2-Iodo-1,1,1-Trifluoropropane
CAS No.	113402-77-0
Molecular Formula	C3H2ClF3I
Molecular Weight	280.30 g/mol
Synonyms	1,1,1-Trifluoro-3-chloro-2-iodopropane; 2-Iodo-3-chloro-1,1,1-trifluoropropane; 3-Chloro-2-iodo-1,1,1-trifluoropropane; Propane, 3-chloro-2-iodo-1,1,1-trifluoro-; CF3CHIClCH3 (common abbreviation); Halogenated Trifluoropropane Derivative
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-Iodo-1,1,1-Trifluoropropane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistent performance for synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids, bases, and incompatible organic solvents. Due to the presence of halogen atoms, ensure containers are properly sealed to prevent moisture ingress and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~2.1 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.