Description

(4-Chloro-1H-Pyrazol-1-Yl)Acetonitrile is a versatile and high-purity heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its reactive nitrile and chlorinated pyrazole functionalities, enabling the construction of complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it serves as a key precursor for active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other biologically active heterocycles.
• Agrochemical Synthesis: Used as a precursor in the development of next-generation herbicides, fungicides, and insecticides, leveraging its halogenated pyrazole core.
• Material Science Research: Employed in the creation of specialized polymers, ligands for catalysis, and advanced organic electronic materials due to its bifunctional reactivity.
• Chemical Biology & Proteomics: Serves as a versatile linker or tagging reagent in the development of chemical probes and activity-based protein profiling (ABPP) agents.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	(4-Chloro-1H-Pyrazol-1-Yl)Acetonitrile
CAS No.	113336-23-5
Molecular Formula	C5H4ClN3
Molecular Weight	141.56 g/mol
Synonyms	2-(4-Chloro-1H-pyrazol-1-yl)acetonitrile; 1H-Pyrazole-1-acetonitrile, 4-chloro-; (4-Chloro-1H-pyrazol-1-yl)acetonitrile; 4-Chloro-1H-pyrazole-1-acetonitrile; 4-Chloropyrazole-1-acetonitrile; 4-Chloro-1-pyrazolylacetonitrile; Acetonitrile, (4-chloro-1H-pyrazol-1-yl)-
EINECS	Contact for details

Quality Control

Our (4-Chloro-1H-Pyrazol-1-Yl)Acetonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency essential for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.