Description

(1R,4S)-(R)-Bicalutamide Sulfide Camphanic Acid Ester is a high-purity chiral intermediate and resolving agent of significant importance in advanced pharmaceutical synthesis. Its core value lies in enabling the production of enantiomerically pure compounds, which is critical for developing targeted therapeutics with improved efficacy and safety profiles. This compound is essential for R&D laboratories and production facilities specializing in non-steroidal anti-androgens, chiral drug development, and fine chemical manufacturing.

Application

• Chiral Resolution Agent: Critical for the separation and purification of enantiomers in pharmaceutical intermediates, particularly for complex molecules like bicalutamide and related analogs.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) targeting hormone-related conditions.
• Research & Development: Used in academic and industrial R&D for studying stereoselective reactions and developing new synthetic pathways for chiral drugs.
• Process Chemistry: Employed in scale-up and optimization of manufacturing processes for chiral therapeutics, ensuring high optical purity in final products.
• Reference Standard: Acts as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical analysis.

Basic Information

Product Name	(1R,4S)-(R)-Bicalutamide Sulfide Camphanic Acid Ester
CAS No.	113299-39-1
Molecular Formula	C31H34F4N2O4S
Molecular Weight	606.68 g/mol
Synonyms	(1R,4S)-(-)-Bicalutamide Sulfide Camphanic Acid Ester; (R)-Bicalutamide Sulfide Camphanic Acid Ester; (1R,4S)-Bicalutamide Sulfide Camphanate; (1R,4S)-1,7,7-Trimethylbicyclo[2.2.1]heptane-2-carboxylic Acid (4-Cyano-3-(trifluoromethyl)phenyl) (4-fluoro-3-((4-fluorophenyl)sulfonyl)phenyl)carbamate Ester; Bicalutamide Related Compound; Bicalutamide Chiral Derivative; Bicalutamide Sulfide Camphanate Ester
EINECS	Contact for details

Quality Control

Our (1R,4S)-(R)-Bicalutamide Sulfide Camphanic Acid Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, NMR, and mass spectrometry, to ensure high chemical and optical purity suitable for pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We adhere to cGMP principles where applicable to support our global clientele in regulated markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.