Description

6-(4-Acetylpiperazin-1-Yl)-2-Chloro-5-Fluoronicotinonitrile is a high-purity, advanced pharmaceutical intermediate featuring a substituted nicotinonitrile core with a piperazine moiety. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Synthesis: Serves as a core structure in the synthesis of potential kinase inhibitors for cancer therapy.
• CNS Drug Development: Employed in the construction of molecules targeting neurological disorders.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and non-commercial drug batches.
• Academic Research: Utilized in university and institutional labs for exploratory chemical biology and pharmacology studies.

Basic Information

Product Name	6-(4-Acetylpiperazin-1-Yl)-2-Chloro-5-Fluoronicotinonitrile
CAS No.	113237-21-1
Molecular Formula	C12H11ClFN5O
Molecular Weight	295.70 g/mol
Synonyms	2-Chloro-5-fluoro-6-(4-acetyl-1-piperazinyl)-3-pyridinecarbonitrile; 2-Chloro-5-fluoro-6-(4-acetylpiperazin-1-yl)nicotinonitrile; 6-(4-Acetyl-1-piperazinyl)-2-chloro-5-fluoronicotinonitrile; 2-Chloro-5-fluoro-6-(4-acetylpiperazin-1-yl)pyridine-3-carbonitrile; 113237-21-1; 6-(4-Acetylpiperazin-1-yl)-2-chloro-5-fluoronicotinonitrile
EINECS	Contact for details

Quality Control

Our 6-(4-Acetylpiperazin-1-Yl)-2-Chloro-5-Fluoronicotinonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.