Description

1,6-Diazabicyclo[3.1.0]Hexane-5-Carboxamide,6-Chloro-n-Methyl-,[1S-(1-α-,5-α-,6-α-)]-(9Ci) is a high-purity, stereochemically defined bicyclic organic compound with the CAS registry number 113085-29-3. This advanced pharmaceutical intermediate is valued for its unique, rigid molecular scaffold, which is critical for imparting specific biological activity and metabolic stability in drug candidates. It is primarily sought after by research and development teams in the pharmaceutical and biotechnology sectors for the synthesis of novel therapeutic agents, particularly in areas requiring precise chiral control.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical development.
• Medicinal Chemistry Research: Used as a core scaffold for designing and optimizing new drug candidates with targeted receptor binding.
• Protease Inhibitor Development: Potential application in the creation of inhibitors for specific enzyme targets due to its diazabicyclo structure.
• Chemical Biology Probes: Serves as a specialized molecular tool for studying biological pathways and protein function.
• Asymmetric Synthesis: Utilized in chiral synthesis where its defined stereochemistry [1S-(1α,5α,6α)-] is essential for producing enantiomerically pure compounds.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and process development for global clients.

Basic Information

Product Name	1,6-Diazabicyclo[3.1.0]Hexane-5-Carboxamide,6-Chloro-n-Methyl-,[1S-(1-α-,5-α-,6-α-)]-(9Ci)
CAS No.	113085-29-3
Molecular Formula	C7H10ClN3O
Molecular Weight	187.63 g/mol
Synonyms	(1S,5S,6S)-6-Chloro-N-methyl-1,6-diazabicyclo[3.1.0]hexane-5-carboxamide; (1S,5S,6S)-6-Chloro-N-methyl-1,6-diazabicyclo[3.1.0]hexane-5-carboxamide (9CI); 6-Chloro-N-methyl-1,6-diazabicyclo[3.1.0]hexane-5-carboxamide, (1S,5S,6S)-; 1,6-Diazabicyclo[3.1.0]hexane-5-carboxamide, 6-chloro-N-methyl-, (1S,5S,6S)-; (1α,5α,6α)-6-Chloro-N-methyl-1,6-diazabicyclo[3.1.0]hexane-5-carboxamide
EINECS	Contact for details

Quality Control

Our 1,6-Diazabicyclo[3.1.0]Hexane-5-Carboxamide,6-Chloro-n-Methyl-,[1S-(1-α-,5-α-,6-α-)]-(9Ci) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC for assay and purity and chiral analysis to confirm stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.