Description

2-(4-Bromo-3-Methoxyphenyl)Acetonitrile is a versatile brominated aromatic nitrile building block, essential for advanced organic synthesis and pharmaceutical research. Its molecular structure, featuring both a bromine substituent and a methoxy group, makes it a critical intermediate for constructing complex molecules through cross-coupling and functional group transformations. This high-purity compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a substituted phenylacetonitrile scaffold.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the bromine atom serves as a handle for further derivatization.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal-catalyzed reactions.
• Material Science Research: Employed in the synthesis of organic electronic materials, liquid crystals, and advanced polymers.
• Cross-Coupling Reactions: The bromine moiety makes it an excellent substrate for Suzuki, Heck, and Buchwald-Hartwig amination reactions.
• Academic & Contract Research: A valuable reagent for methodological studies and the discovery of new chemical entities in university and CRO laboratories.

Basic Information

Product Name	2-(4-Bromo-3-Methoxyphenyl)Acetonitrile
CAS No.	113081-50-8
Molecular Formula	C9H8BrNO
Molecular Weight	226.07 g/mol
Synonyms	(4-Bromo-3-methoxyphenyl)acetonitrile; 4'-Bromo-3'-methoxyphenylacetonitrile; 2-(4-Bromo-3-methoxyphenyl)ethanenitrile; 4-Bromo-3-methoxybenzyl cyanide; α-Cyano-4-bromo-3-methoxytoluene; p-Bromo-m-methoxyphenylacetonitrile; 1-(4-Bromo-3-methoxyphenyl)-2-cyanoethane
EINECS	Contact for details

Quality Control

Our 2-(4-Bromo-3-Methoxyphenyl)Acetonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our commitment to traceability and reproducibility supports your regulatory and process development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.