Description

Biotin-Peg5-Amine CAS NO 113072-75-6 is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring a biotin group for affinity binding and a terminal amine for conjugation. This compound is essential for creating stable, site-specific bioconjugates used in advanced diagnostics and therapeutic development. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for applications such as drug delivery systems, biosensor development, and affinity chromatography.

Application

• Bioconjugation and Drug Delivery: Serves as a critical spacer and linker for attaching biotinylated drugs, peptides, or proteins to nanoparticles, antibodies, or other carriers to enhance targeting and pharmacokinetics.
• Diagnostic Assay Development: Used to functionalize surfaces (e.g., chips, plates, beads) with biotin for capturing streptavidin-conjugated detection molecules in ELISA, lateral flow assays, and other immunoassays.
• Affinity Purification: Immobilized onto solid supports to create resins for the purification of streptavidin/avidin-tagged proteins, antibodies, or nucleic acids.
• Biosensor and Probe Design: Conjugated to fluorescent dyes, quenchers, or other reporter molecules to create sensitive molecular probes for imaging and detection.
• ADC (Antibody-Drug Conjugate) Research: Functions as a cleavable or non-cleavable linker component in the synthesis of novel ADCs, connecting cytotoxic payloads to targeting antibodies.
• Material Science and Surface Modification: Employed to introduce biotin groups onto polymers, hydrogels, or nanomaterials to impart specific bio-recognition properties.

Basic Information

Product Name	Biotin-Peg5-Amine
CAS No.	113072-75-6
Molecular Formula	C27H51N5O8S
Molecular Weight	605.78 g/mol
Synonyms	5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(17-amino-3,6,9,12,15-pentaoxaheptadecyl)pentanamide; Biotin-PEG5-NH2; Biotin-PEG5-amine; Biotinylated PEG5 amine; (+)-Biotin-PEG5-amine; N-(17-Amino-3,6,9,12,15-pentaoxaheptadecyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide; Biotin-amido-PEG5-amine
EINECS	Contact for details

Quality Control

Our Biotin-Peg5-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We support cGMP-grade production for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and under an inert atmosphere. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, water, and common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.