Description

2-(Trifluoromethyl)Benzylsulfonamide is a specialized fluorinated sulfonamide derivative, a key building block in advanced organic synthesis. Its value lies in the unique combination of the sulfonamide pharmacophore and the electron-withdrawing trifluoromethyl group, which can significantly alter the physicochemical and biological properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, serving as a critical intermediate in the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in areas targeting enzymes where sulfonamide groups act as inhibitors.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of the sulfonamide moiety.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers with specific surface properties or chemical resistance.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and protein function.
• Ligand Development: Useful in medicinal chemistry for creating ligands with enhanced binding affinity and metabolic stability due to the fluorine atoms.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	2-(Trifluoromethyl)Benzylsulfonamide
CAS No.	112941-35-2
Molecular Formula	C8H8F3NO2S
Molecular Weight	239.21 g/mol
Synonyms	α,α,α-Trifluoro-o-toluenesulfonamide; 2-(Trifluoromethyl)benzenemethanesulfonamide; (2-(Trifluoromethyl)phenyl)methanesulfonamide; 1-(Trifluoromethyl)-2-(sulfamoylmethyl)benzene; o-Trifluoromethylbenzylsulfonamide; 2-(Trifluoromethyl)benzylsulfonylamide; Benzenemethanesulfonamide, α,α,α-trifluoro-2-methyl-; EINECS Not Listed

Quality Control

Our 2-(Trifluoromethyl)Benzylsulfonamide is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.