Description

Fmoc-Metrp-Oh CAS NO 112913-63-0 is a protected amino acid derivative, specifically the Fmoc (9-fluorenylmethoxycarbonyl) derivative of methionine. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and sequential assembly of complex peptides. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity intermediates for the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key monomer for the automated synthesis of peptides containing methionine residues.
• Pharmaceutical Research: Used in the discovery and development of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation: Serves as a precursor for creating peptide-protein or peptide-small molecule conjugates for targeted therapies.
• Combinatorial Chemistry: A valuable reagent in libraries for high-throughput screening of bioactive compounds.
• Biochemical Tool Development: Employed in the synthesis of substrates, inhibitors, and probes for enzymatic and cellular studies.
• Academic & Industrial R&D: Fundamental reagent for universities, CROs (Contract Research Organizations), and CDMOs (Contract Development and Manufacturing Organizations).

Basic Information

Product Name	Fmoc-Metrp-Oh
CAS No.	112913-63-0
Molecular Formula	C₂₀H₂₁NO₄S
Molecular Weight	371.45 g/mol
Synonyms	Fmoc-Met-OH; Fmoc-L-Methionine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-methionine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-4-methylsulfanylbutanoic acid; N-Fmoc-L-methionine; Fmoc-Methionine; Fmoc-L-Met-OH; Nα-Fmoc-L-methionine
EINECS	Contact for details

Quality Control

Our Fmoc-Metrp-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive applications like peptide synthesis. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity. A Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	-20.0° to -24.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.