Description

Imipramine-D3 Hydrochloride 98 Atom % D is a high-purity, deuterium-labeled internal standard essential for precise quantitative analysis in modern laboratories. This stable isotope-labeled compound is critical for ensuring accuracy and reliability in sensitive analytical methods, particularly in pharmacokinetic and metabolic studies. It is primarily used by researchers and quality control professionals in the pharmaceutical, forensic, and clinical diagnostics industries.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for the accurate measurement of imipramine and its metabolites in biological matrices.
• Pharmaceutical R&D: Facilitates drug metabolism and pharmacokinetics (DMPK) studies, enabling precise tracking of the parent drug compound during development.
• Forensic Toxicology: Employed in the confirmation and quantification of tricyclic antidepressants in post-mortem and clinical toxicology screenings.
• Clinical Research: Supports therapeutic drug monitoring (TDM) studies to correlate drug plasma levels with efficacy and side effects.
• Method Development & Validation: Serves as a critical component in developing and validating robust, regulatory-compliant analytical methods (e.g., following FDA or EMA guidelines).
• Quality Control (QC) Testing: Used by pharmaceutical manufacturers for in-process testing and batch release analysis of imipramine-based drug products.

Basic Information

Product Name	Imipramine-D3 Hydrochloride 98 Atom % D
CAS No.	112898-42-7
Molecular Formula	C19H21D3N2·HCl
Molecular Weight	319.86 g/mol
Synonyms	Imipramine-d3 HCl; 5-[3-(Dimethyl-d6-amino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine Hydrochloride; 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-bis(methyl-d3)propan-1-amine Hydrochloride; Desipramine-d3 Impurity; Deuterated Imipramine Hydrochloride; N-(γ-Dimethylaminopropyl)iminodibenzyl-d3 Hydrochloride; Tofranil-d3 Hydrochloride
EINECS	Contact for details

Quality Control

Our Imipramine-D3 Hydrochloride 98 Atom % D is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR and mass spectrometry, to confirm isotopic enrichment and chemical purity, ensuring it meets the exacting standards required for analytical applications. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic abundance, and analytical results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (Atom % D)	≥98%
Chemical Purity	≥95%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.