Description

Fmoc-D-Aspartic Acid β-tert-Butyl Ester is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is specifically engineered to provide orthogonal protection for the aspartic acid side chain, preventing unwanted side reactions during peptide chain assembly and enabling the synthesis of complex peptides and proteins. It is a critical building block for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the automated and manual synthesis of peptides containing D-aspartic acid residues.
• Pharmaceutical R&D: Used in the research and development of novel peptide-based drugs, including hormone analogs, antimicrobial peptides, and targeted therapeutics.
• Combinatorial Chemistry: Serves as a building block in libraries for drug discovery and the study of structure-activity relationships (SAR).
• Bioconjugation: Facilitates the site-specific modification of proteins and other biomolecules by providing a selectively deprotectable carboxylic acid group.
• Production of Complex Peptides: Essential for synthesizing peptides with aspartic acid at specific positions, particularly where side-chain reactivity must be controlled.
• Biochemical Research: Used as a standard or reagent in studies of enzyme specificity, peptide folding, and molecular recognition.

Basic Information

Product Name	Fmoc-D-Aspartic Acid β-tert-Butyl Ester
CAS No.	112883-39-3
Molecular Formula	C23H25NO6
Molecular Weight	411.45 g/mol
Synonyms	Fmoc-D-Asp(OtBu)-OH; N-(9-Fluorenylmethoxycarbonyl)-D-aspartic acid β-tert-butyl ester; Fmoc-Asp(OtBu)-OH (D-form); (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)butanedioic acid 4-tert-butyl ester; N-α-Fmoc-D-aspartic acid 4-tert-butyl ester; Fmoc-D-Asp(OtBu)-OH; D-Aspartic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 4-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our Fmoc-D-Aspartic Acid β-tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee consistent quality, lot-to-lot traceability, and compliance with research and cGMP-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.