Description

(R)-Naproxen Acyl-B-D-Glucuronide is a specific, phase II metabolite of the non-steroidal anti-inflammatory drug (NSAID) (R)-Naproxen. This compound is of significant value for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical reference standards. It is primarily required by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in bioanalytical method development, metabolite identification, and regulatory compliance testing.

Application

• Bioanalytical Reference Standard: Used as a certified standard for the accurate quantification of (R)-Naproxen and its metabolites in biological matrices (e.g., plasma, urine) via LC-MS/MS or HPLC.
• Metabolite Profiling & Identification: Essential for in vitro and in vivo studies to map the metabolic pathways of (R)-Naproxen, supporting drug safety and efficacy assessments.
• Pharmacokinetic (PK) Studies: Employed to understand the absorption, distribution, metabolism, and excretion (ADME) profile of the parent drug.
• Enzyme Activity Assays: Serves as a substrate or reference compound in studies investigating the activity of UDP-glucuronosyltransferase (UGT) enzymes.
• Regulatory Submission Support: Provides critical data for regulatory filings (e.g., with the FDA, EMA) requiring comprehensive metabolite characterization.
• Quality Control in Manufacturing: Acts as a system suitability standard in the quality control of (R)-Naproxen active pharmaceutical ingredient (API) and related formulations.

Basic Information

Product Name	(R)-Naproxen Acyl-B-D-Glucuronide
CAS No.	112828-15-6
Molecular Formula	C23H24O10
Molecular Weight	460.43 g/mol
Synonyms	(R)-Naproxen Glucuronide; (R)-Naproxen Acyl-β-D-Glucuronide; (R)-Naproxen 1-O-β-Acylglucuronide; (2R)-2-(6-Methoxy-2-naphthyl)propanoic acid 1-(β-D-glucopyranuronosyl) ester; (R)-Naproxen β-1-O-Acyl Glucuronide; Naproxen (R enantiomer) Acyl Glucuronide; (R)-NAP-Gluc
EINECS	Contact for details

Quality Control

Our (R)-Naproxen Acyl-B-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and identity confirmation, meeting the stringent requirements for reference standard applications. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), identity (by NMR, MS), and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Allow the product to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	≤ 5.0% total
Water Content (KF)	≤ 2.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.