Description

Ropivacaine-Et-S-Hcl is a high-purity pharmaceutical intermediate and reference standard, specifically the hydrochloride salt of the S-enantiomer of ropivacaine. This compound is critical for research, development, and quality control processes in the synthesis of modern local anesthetics. It is primarily utilized by pharmaceutical manufacturers, analytical laboratories, and R&D institutions focused on developing enantiomerically pure active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of the S-enantiomer of Ropivacaine API.
• Analytical Reference Standard: Used for method development, validation, and quality control (HPLC, GC, LC-MS) to ensure the purity and identity of final drug products.
• Pharmacological Research: Employed in preclinical studies to investigate the stereospecific activity, pharmacokinetics, and toxicity profile of ropivacaine enantiomers.
• Impurity Standard: Serves as a certified reference material for identifying and quantifying related substances in Ropivacaine drug substance and finished formulations.
• Process Chemistry: Used in the development and optimization of asymmetric synthesis and chiral separation processes.

Basic Information

Product Name	Ropivacaine-Et-S-Hcl
CAS No.	112773-86-1
Molecular Formula	C17H27ClN2O
Molecular Weight	310.86 g/mol
Synonyms	(S)-Ropivacaine Hydrochloride; (S)-1-Propyl-2',6'-pipecoloxylidide Hydrochloride; (S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide Hydrochloride; S-(-)-Ropivacaine HCl; Levobupivacaine Related Compound (structural analog); Naropin Impurity S; Chiral Ropivacaine Salt; Local Anesthetic Intermediate.
EINECS	Contact for details

Quality Control

Our Ropivacaine-Et-S-Hcl is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity assay, identification, and impurity profiling, to ensure it meets stringent specifications for pharmaceutical research. A detailed Certificate of Analysis (COA) providing batch-specific results is supplied with every order to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.