Description

Insulin, n-Me-Ile(2A)- CAS NO 112659-21-9 is a chemically modified insulin analogue where the isoleucine residue at position 2 of the A-chain is N-methylated. This specific modification is of significant interest in pharmaceutical research for studying insulin receptor interactions, stability, and metabolic pathways. It serves as a critical reference standard and intermediate for the development of novel therapeutic peptides. This high-purity compound is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in advanced diabetes research and peptide drug discovery.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for analytical method development, validation, and quality control of insulin-based therapeutics.
• Biochemical Research: Employed in structure-activity relationship (SAR) studies to understand the impact of A-chain modifications on insulin's biological activity and stability.
• Drug Discovery Intermediate: Serves as a key building block or precursor in the synthesis of novel, long-acting, or rapid-acting insulin analogue candidates.
• Metabolic Studies: Utilized in in vitro and ex vivo experiments to investigate insulin signaling pathways, receptor binding kinetics, and downstream effects.
• Peptide Chemistry Research: Acts as a model compound for studying N-methylation effects on peptide conformation, protease resistance, and physicochemical properties.

Basic Information

Product Name	Insulin, n-Me-Ile(2A)- CAS NO 112659-21-9
CAS No.	112659-21-9
Molecular Formula	C257H383N65O77S6
Molecular Weight	~5807.5 g/mol
Synonyms	N-Methyl-Isoleucine(2)-Insulin A-Chain; Insulin A-Chain (N-Me-Ile2); N-Me-Ile2-Insulin; N-Methylated Insulin Analogue; [N-Me-Ile2]-Insulin; Insulin derivative (Ile(A2)-N-methyl); CAS 112659-21-9
EINECS	Contact for details

Quality Control

Our Insulin, n-Me-Ile(2A)- is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and peptide content determination. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 2.0%
Biological Activity	Assessed by receptor binding assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.