Description

Insulin-Like Growth Factor 1, Des-(1-3)- is a truncated, biologically active analog of human IGF-1, known for its enhanced potency and altered receptor binding profile. This high-purity peptide is critical for advanced research and development in life sciences, offering a valuable tool for studying growth factor signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on metabolic research, cell culture applications, and therapeutic development.

Application

• Cell Culture & Tissue Engineering: Used as a potent mitogen to promote cell proliferation, differentiation, and survival in various mammalian cell culture systems.
• Metabolic Research: Serves as a key reagent in studies investigating insulin-like activity, glucose metabolism, and anabolic processes.
• Pharmaceutical R&D: Employed in the discovery and development of novel therapeutics targeting the IGF-1 receptor pathway for conditions like growth disorders and certain cancers.
• Biochemical Assay Development: Acts as a standard or active component in ELISA kits, receptor binding assays, and other diagnostic or research kits.
• Signal Transduction Studies: Essential for elucidating the mechanisms of the IGF-1R and hybrid insulin/IGF-1 receptor signaling cascades.
• Academic & Basic Research: A fundamental tool for university and institutional labs studying endocrinology, developmental biology, and aging.

Basic Information

Product Name	Insulin-Like Growth Factor 1, Des-(1-3)-
CAS No.	112603-35-7
Molecular Formula	C357H559N101O115S7
Molecular Weight	8070.9 g/mol (approximate)
Synonyms	Des(1-3)IGF-I; IGF-I Des-(1-3); Long®R3 IGF-I; Insulin-like growth factor I (1-3) deleted; IGF-1 Des; Mechano Growth Factor (MGF) analogue; Truncated IGF-1; [Des-1-3]-IGF-1
EINECS	Contact for details

Quality Control

Our Insulin-Like Growth Factor 1, Des-(1-3)- is manufactured under stringent conditions to ensure the highest standards of purity and biological activity. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results from advanced analytical techniques including HPLC, MS, and peptide mapping. We are committed to supplying material suitable for research and development applications, with purity levels typically exceeding 95%.

Storage

Preserve in a tightly closed container, protected from light. Store lyophilized powder at -20°C or below. For long-term storage, keep at -70°C to -80°C. This material is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. Reconstituted solutions should be aliquoted and stored at -20°C or lower, avoiding repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Water Content (K.F.)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Biological Activity	Assessed by cell proliferation assay
Endotoxin Level	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.