Description

Keto Itraconazole CAS NO 112560-33-5 is a key pharmaceutical intermediate, specifically the ketone derivative of the broad-spectrum antifungal agent Itraconazole. This compound is of critical importance in the synthesis of the final active pharmaceutical ingredient (API), ensuring the quality and efficacy of the finished drug product. It is primarily required by manufacturers in the pharmaceutical and fine chemical industries engaged in the production of advanced antifungal medications.

Application

• Primary Intermediate in the synthesis of Itraconazole API.
• Research & Development for novel triazole-based antifungal agents.
• Process Chemistry for scale-up and optimization of Itraconazole manufacturing routes.
• Reference Standard for analytical method development and quality control in pharmaceutical labs.
• Fine Chemical Synthesis for creating specialized derivatives for biological testing.

Basic Information

Product Name	Keto Itraconazole
CAS No.	112560-33-5
Molecular Formula	C35H38Cl2N8O4
Molecular Weight	705.63 g/mol
Synonyms	Itraconazole Ketone; Itraconazole Impurity C; 4-[4-[4-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2,4-dihydro-2-[(1S)-1-methylpropyl]-3H-1,2,4-triazol-3-one; (2R,4S)-rel-2-(2,4-Dichlorophenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]-1,3-dioxolan-4-yl]methyl 4-[4-[4-[2,4-dihydro-2-(1-methylpropyl)-3-oxo-1,2,4-triazol-1-yl]phenyl]-1-piperazinyl]phenyl ether; UNII-8V07163P3O; Itraconazole Related Compound C
EINECS	Contact for details

Quality Control

Our Keto Itraconazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets stringent specifications for pharmaceutical intermediates. Certificates of Analysis (COA) are provided and traceability is maintained for full supply chain transparency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.