Description

Difluoro-(4-Methoxy-Phenyl)-Acetic Acid Ethyl Ester is a high-purity fluorinated building block essential for advanced organic synthesis. This compound is valued for its role in introducing difluoromethyl and methoxyphenyl motifs into target molecules, enabling the fine-tuning of physicochemical properties. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting metabolic and central nervous system diseases.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the development of fluorinated organic electronic materials for displays and lighting applications.
• Organic Synthesis Reagent: A versatile reagent for constructing complex molecules in academic and industrial R&D laboratories, especially in cross-coupling and esterification reactions.
• Fluorine Chemistry Research: Fundamental compound for studying the effects of fluorine substitution on aromatic systems and ester reactivity.

Basic Information

Item	Details
Product Name	Difluoro-(4-Methoxy-Phenyl)-Acetic Acid Ethyl Ester
CAS No.	112545-98-9
Molecular Formula	C11H12F2O3
Molecular Weight	230.21 g/mol
Synonyms	Ethyl 2,2-Difluoro-2-(4-methoxyphenyl)acetate; 2-(4-Methoxyphenyl)-2,2-difluoroacetic Acid Ethyl Ester; 4-Methoxy-α,α-difluorobenzeneacetic Acid Ethyl Ester; Ethyl (4-Methoxyphenyl)difluoroacetate; Difluoro(4-methoxyphenyl)acetic Acid Ethyl Ester; DFMPAE; CAS 112545-98-9
EINECS	Contact for details

Quality Control

Every batch of Difluoro-(4-Methoxy-Phenyl)-Acetic Acid Ethyl Ester is manufactured under strict quality management systems. We employ advanced analytical techniques including GC, HPLC, NMR, and IR spectroscopy to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, and custom purity grades to meet specific project requirements are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.