Description

2-Fluoro-1,1-Dimethyl-Ethylamine is a versatile fluorinated amine building block of significant interest in advanced organic synthesis. Its value lies in the strategic incorporation of fluorine and a sterically hindered amine group, which can dramatically alter the physicochemical and biological properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to optimize lead compounds for enhanced activity, metabolic stability, and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in CNS and metabolic disease research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the fluorine atom improves lipophilicity and target binding.
• Ligand & Catalyst Development: Serves as a precursor for chiral auxiliaries and ligands in asymmetric catalysis.
• Material Science: Incorporated into specialty polymers and coatings to impart unique surface properties and chemical resistance.
• Fluorine Chemistry Research: A valuable reagent for studying structure-activity relationships (SAR) in medicinal and synthetic chemistry.
• Peptide Mimetics: Used to introduce fluorinated, non-natural amino acid analogs into peptide backbones.

Basic Information

Item	Details
Product Name	2-Fluoro-1,1-Dimethyl-Ethylamine
CAS No.	112433-52-0
Molecular Formula	C4H10FN
Molecular Weight	91.13 g/mol
Synonyms	1-Amino-2-fluoro-2-methylpropane; 2-Fluoro-tert-butylamine; 2-Fluoro-1,1-dimethylethylamine; 2-Fluoro-N,N-dimethyl-ethanamine; (2-Fluoro-1,1-dimethylethyl)amine; tert-Butylamine, 2-fluoro-; 2-Fluoro-tert-butylamine hydrochloride (salt form); α-Fluoro-tert-butylamine
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-1,1-Dimethyl-Ethylamine is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemicals and pharmaceutical intermediates. Comprehensive analytical testing, including GC, HPLC, and NMR, is performed to verify identity, purity, and impurity profiles. A Certificate of Analysis (COA) detailing all test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.